Pili in Mycobacterium Tuberculosis Structure, Function, and Therapeutic Advances

Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTB). The book examines the structure of pili shown under electron and atomic force microscopy and, by using whole genome sequencing, outlines the importance of pili in MTB. It also explores the role of pili in bacteria?host interactions and in drug development and delivery.

The book provides an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. It also examines the structure of pili and the preparation of MTB for electronic and atomic microscopy. It explores the various life cycles of pili, the susceptibility patterns of MTB, the differences of pili formation in MTB, and their role in increase surveillance. It goes on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria?host interactions. Lastly, it explores the development of new drugs and their therapeutic delivery by pili.

About the authors

1. The structure and function of pili in bacteria
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi and Ali Akbar Velayati

1.1 The taxonomy of the genus Mycobacterium
1.2 Different pili in bacteria genies
1.3 The pili at genomic level
1.4 The role and function of pili in diseases
References
Further reading

2. The structure of pili under electron and atomic force microscopy
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi and Ali Akbar Velayati

2.1 Preparation of Mycobacterium tuberculosis for electron microscopy
2.2 Preparation of Mycobacterium tuberculosis for atomic force microscopy
2.3 Preparation of different life cycle and susceptibility pattern of Mycobacterium tuberculosis
2.4 Differences of pili formation in Mycobacterium tuberculosis and their role in increase surveillance
References
Further reading

3. The pili at genomic level
Poopak Farnia, Jalaledin Ghanavi, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Parissa Farnia and Ali Akbar Velayati

3.1 Whole genome of Mycobacterium tuberculosis
3.2 Genes related to pili expression and function in tuberculosis and other Mycobacterium species
References
Further reading

4. The design for drug delivery using pili in Mycobacterium tuberculosis
Jalaledin Ghanavi, Poopak Farnia, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Parissa Farnia and Ali Akbar Velayati

4.1 Pili application in drug delivery in different bacteria
4.2 Pili application in drug delivery in mycobacteria
References
Further reading

5. Role of Mycobacterium tuberculosis pili in host
Parissa Farnia, Poopak Farnia, Jafar Aghajani, Saman Ayoubi, Saeid Besharati, Jalaledin Ghanavi and Ali Akbar Velayati

5.1 The role of bacteria pili in host
5.2 Role of Mycobacterium tuberculosis pili in host
References
Further reading

Dr. Ali Akbar Velayati is the Director of the National Research Institute of Tuberculosis and Lung Diseases (NRITLD) at the Shahid Beheshti University of Medical Sciences. He is a Full Professor of Pediatric Infectious Diseases, and he has guided more than 300 MD and PhD students. He is also the Head of Mycobacteriology Research Center (MRC) in NRITLD, where he directly monitors the basic and clinical trial on tuberculosis. Dr. Velayati is the President of the Asian African Society of Mycobacteriology and of the Society of Biomedical and Biotechnology Scientists. He is the Chief Editor of the International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal.
Dr. Parissa Farnia is the Director of the Iranian National Reference Tuberculosis Laboratory (INRT) at the Mycobacteriology Research Center (MRC) in the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Her expertise and research interests include mycobacteriology, infectious diseases, and tuberculosis. She has published in multiple international journals such as Journal of Clinical Microbiology, Chest, Clinical infectious Diseases, and the International Journal of Tuberculosis and Lung Disease and serves on several editorial boards including International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal.

• Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB
• Introduces seven types of pili in MTB
• Explains the mechanism of bacteria–host attachment and importance of this phenomena in MTB pili and other bacteria
• Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells